The duration of treatment with N-acetylcyseteine depends on the type of ingestion and the presence of transaminitis. The important steps in management include hemodynamic stabilization, decontamination, and administration of N-acetylcysteine- the specific antidote. Acetaminophen poisoning may occur either as a result of acute ingestion or following cumulative effects. Eventhough its not the commonest cause of fulminant hepatitis in India poisoning is still common and confusions prevail regarding the optimum and modern regimens in Indian population.
Acetaminophen poisoning is the most common cause of fulminant hepatitis and drug induced liver injury worldwide.
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